Microsporum canis infection mimics pemphigus erythematosus

We report a 55-year-old Japanese woman with a two-month history of multiple pruritic erythema and erosion on her face and neck. Based on the clinical appearance, we initially diagnosed her as having pemphigus erythematosus. However, the results of a histopathological examination and a direct immunof...

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Bibliographic Details
Main Authors: Hiroo Amano (Author), Chikako Kishi (Author), Yoko Yokoyama (Author), Akira Shimizu (Author), Kazushi Anzawa (Author), Takashi Mochizuki (Author), Osamu Ishikawa (Author)
Format: Book
Published: Wolters Kluwer Medknow Publications, 2013-01-01T00:00:00Z.
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Summary:We report a 55-year-old Japanese woman with a two-month history of multiple pruritic erythema and erosion on her face and neck. Based on the clinical appearance, we initially diagnosed her as having pemphigus erythematosus. However, the results of a histopathological examination and a direct immunofluorescence study did not support the initial diagnosis. Additionally, anti-desmoglein 1 and 3 antibodies were all negative. Subsequently, a microscopic examination of scales revealed filaments of fungi and a fungal culture was negative for macroconidium. Using molecular biology techniques, we identified the fungus as Microsporum canis, which causes a zoonotic infection. The immune reaction to the fungi could be drastic and therefore, the eruption sometimes displays atypical clinical manifestations.
Item Description:0019-5154
1998-3611
10.4103/0019-5154.110866