Expression of MMP-2 and TIMP-1 in Renal Tissue of Patients with Chronic Active Antibody-mediated Renal Graft Rejection
<p>Abstract</p> <p>Objective</p> <p>To investigate the expression of matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metallopropteinase-1 (TIMP-1) in the renal allografts of patients with chronic active antibody-mediated rejection (AMR), and to explore their...
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BMC,
2012-10-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_eadad9f766154f1bbb5ea9e23bce4593 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Yan Qiang |e author |
| 700 | 1 | 0 | |a Sui Weiguo |e author |
| 700 | 1 | 0 | |a Wang Baoyao |e author |
| 700 | 1 | 0 | |a Zou Hequn |e author |
| 700 | 1 | 0 | |a Zou Guimian |e author |
| 700 | 1 | 0 | |a Luo Hao |e author |
| 245 | 0 | 0 | |a Expression of MMP-2 and TIMP-1 in Renal Tissue of Patients with Chronic Active Antibody-mediated Renal Graft Rejection |
| 260 | |b BMC, |c 2012-10-01T00:00:00Z. | ||
| 500 | |a 10.1186/1746-1596-7-141 | ||
| 500 | |a 1746-1596 | ||
| 520 | |a <p>Abstract</p> <p>Objective</p> <p>To investigate the expression of matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metallopropteinase-1 (TIMP-1) in the renal allografts of patients with chronic active antibody-mediated rejection (AMR), and to explore their role in the pathogenesis of AMR.</p> <p>Methods</p> <p>Immunohistochemistry assay and computer-assisted image analysis were used to detect the expression of MMP-2 and TIMP-1 in the renal allografts with interstitial fibrosis and tubular atrophy (IF/TA) in 46 transplant recipients and 15 normal renal tissue specimens as the controls. The association of the expression level of either MMP-2 or TIMP-1 with the pathological grade of IF/TA in AMR was analyzed.</p> <p>Results</p> <p>The expression of either MMP-2 or TIMP-1 was significantly increased in the renal allografts of the recipients as compared with the normal renal tissue (<it>P</it> < 0.05). MMP-2 expression tended to decrease, while TIMP-1 and serum creatinine increased along with the increase of pathological grade of IF/TA (<it>P</it> < 0.05). In IF/TA groups, the expression of TIMP-1 was positively correlated to serum creatinine level (r = 0.718, <it>P</it> < 0.05).</p> <p>Conclusions</p> <p>It is suggested by the results that abnormal expressions of MMP-2 and TIMP-1 might play roles in the development of renal fibrosis in chronic AMR.</p> <p>Virtual Slides</p> <p>The virtual slide(s) for this article can be found here: <url>http://www.diagnosticpathology.diagnomx.eu/vs/1128474926172838</url></p> | ||
| 546 | |a EN | ||
| 690 | |a Matrix metalloproteinase-2 | ||
| 690 | |a Tissue inhibitor of metalloproteinase-1 | ||
| 690 | |a Chronic active antibody-mediate rejection | ||
| 690 | |a Interstitial fibrosis and tubular atrophy | ||
| 690 | |a Pathology | ||
| 690 | |a RB1-214 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Diagnostic Pathology, Vol 7, Iss 1, p 141 (2012) | |
| 787 | 0 | |n http://www.diagnosticpathology.org/content/7/1/141 | |
| 787 | 0 | |n https://doaj.org/toc/1746-1596 | |
| 856 | 4 | 1 | |u https://doaj.org/article/eadad9f766154f1bbb5ea9e23bce4593 |z Connect to this object online. |