Exposure-Response Modeling to Support Dosing Selection for Phase IIb Development of Kukoamine B in Sepsis Patients

• Main Authors: Huanhuan Wang (Author), Xiaoyun Hu (Author), Teng Wang (Author), Cheng Cui (Author), Ji Jiang (Author), Kai Dong (Author), Shuai Chen (Author), Chunyan Jin (Author), Qian Zhao (Author), Bin Du (Author), Pei Hu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim: Kukoamine B, a small molecule compound, is being developed for the treatment of sepsis in a Phase II clinical trial. The objective of this study was to optimize dosing selection for a Phase IIb clinical trial using an exposure-response model.Methods: Data of 34 sepsis patients from a Phase IIa...