Bulgecin A: The Key to a Broad‐Spectrum Inhibitor  That Targets Lytic Transglycosylases

• Main Authors: Allison H. Williams (Author), Richard Wheeler (Author), Constance Thiriau (Author), Ahmed Haouz (Author), Muhamed‐Kheir Taha (Author), Ivo G. Boneca (Author)
• Format: Book
• Published: MDPI AG, 2017-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lytic transglycosylases (Lts) are involved in recycling, cell division, and metabolism of the peptidoglycan. They have been understudied for their usefulness as potential antibacterial targets due to their high redundancy in Gram‐negative bacteria. Bulgecin A is an O‐sulphonated glycopeptide that ta...