Neuropharmacological Activities of <i>Ceiba aesculifolia</i> (Kunth) Britten & Baker f (Malvaceae)

• Main Authors: Chrystyan Iván Bustos-Gómez (Author), Deisy Gasca-Martínez (Author), Eunice Yáñez-Barrientos (Author), Sergio Hidalgo-Figueroa (Author), Maria L. Gonzalez-Rivera (Author), Juan Carlos Barragan-Galvez (Author), Juan Ramón Zapata-Morales (Author), Mario Isiordia-Espinoza (Author), Alma Rosa Corrales-Escobosa (Author), Angel Josabad Alonso-Castro (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<i>Ceiba aesculifolia</i> (Kunth) Britten & Baker f (Malvaceae) is used for the folk treatment of mood disorders. <i>C. aesculifolia</i> bark was extracted in ethanol, and the extract (CAE) was chemically standardized using gas chromatography-mass spectrometry (GC-MS). This study evaluated the effects of CAE (10-100 mg/kg p.o.) on anxiolytic-like activity, sedation, locomotor activity, depression-like activity, and spatial working memory using in vivo rodent models. A possible mechanism for the anxiolytic-like and antidepressant-like actions induced by CAE was assessed using neurotransmission pathway inhibitors. Myristic acid was one of the compounds found in CAE using GC-MS. This study also evaluated the anxiolytic-like activity and the sedative actions of myristic acid and assessed a possible mechanism of action using neurotransmission pathway inhibitors and an in silico analysis. CAE elicited anxiolytic-like activity and antidepressant-like effects (ED₅₀ = 57 mg/kg). CAE (10-100 mg/kg) did not affect locomotor coordination or induce sedation. The anxiolytic-like and antidepressant-like actions of CAE were reverted by prazosin, suggesting a possible participation of the noradrenergic system. The anxiolytic-like activity of myristic acid was reverted by the co-administration of prazosin and partially reverted by ketanserin. The docking study revealed that myristic acid can form favorable interactions within 5-HT2A and α1A-adrenoreceptor binding pockets.

Item Description

10.3390/ph15121580
1424-8247