Clofazimine pharmacokinetics in HIV‐infected adults with diarrhea: Implications of diarrheal disease on absorption of orally administered therapeutics

• Main Authors: Cindy X. Zhang (Author), Thomas M. Conrad (Author), David Hermann (Author), Melita A. Gordon (Author), Eric Houpt (Author), Pui‐Ying Iroh Tam (Author), Khuzwayo C. Jere (Author), Wilfred Nedi (Author), Darwin J. Operario (Author), Jacob Phulusa (Author), Gerald V. Quinnan Jr (Author), Leigh A. Sawyer (Author), Lynn K. Barrett (Author), Herbert Thole (Author), Neema Toto (Author), Wesley C. Van Voorhis (Author), Samuel L. M. Arnold (Author)
• Format: Book
• Published: Wiley, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Oral drug absorption kinetics are usually established in populations with a properly functioning gastrointestinal tract. However, many diseases and therapeutics can alter gastrointestinal physiology and cause diarrhea. The extent of diarrhea‐associated impact on drug pharmacokinetics has no...