Role of the active zone protein, ELKS, in insulin secretion from pancreatic β-cells

• Hauptverfasser: Mica Ohara-Imaizumi (Verfasst von), Kyota Aoyagi (Verfasst von), Toshihisa Ohtsuka (Verfasst von)
• Format: Buch
• Veröffentlicht: Elsevier, 2019-09-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Background: Insulin is stored within large dense-core granules in pancreatic beta (β)-cells and is released by Ca2+-triggered exocytosis with increasing blood glucose levels. Polarized and targeted secretion of insulin from β-cells in pancreatic islets into the vasculature has been proposed; however...