Role of the active zone protein, ELKS, in insulin secretion from pancreatic β-cells

• Main Authors: Mica Ohara-Imaizumi (Author), Kyota Aoyagi (Author), Toshihisa Ohtsuka (Author)
• Formato: Libro
• Publicado: Elsevier, 2019-09-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Background: Insulin is stored within large dense-core granules in pancreatic beta (β)-cells and is released by Ca2+-triggered exocytosis with increasing blood glucose levels. Polarized and targeted secretion of insulin from β-cells in pancreatic islets into the vasculature has been proposed; however...