Role of the active zone protein, ELKS, in insulin secretion from pancreatic β-cells

• Main Authors: Mica Ohara-Imaizumi (Author), Kyota Aoyagi (Author), Toshihisa Ohtsuka (Author)
• 格式: 圖書
• 出版: Elsevier, 2019-09-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Background: Insulin is stored within large dense-core granules in pancreatic beta (β)-cells and is released by Ca2+-triggered exocytosis with increasing blood glucose levels. Polarized and targeted secretion of insulin from β-cells in pancreatic islets into the vasculature has been proposed; however...