Synthesis and Biological Activities of Pyrazino[1,2-<i>a</i>]indole and Pyrazino[1,2-<i>a</i>]indol-1-one Derivatives
This review concerns the synthesis and biological activities of pyrazino[1,2-<i>a</i>]indoles and pyrazino[1,2-<i>a</i>]indol-1-ones reported since 1997 and the discovery of biological activity of pyrazinoindole derivatives. In the first part, we first presented the synthetic...
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| Format: | Book |
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MDPI AG,
2021-08-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_eb6bde94853b4f2c9e4dd6b5c8f6fede | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Kena Zhang |e author |
| 700 | 1 | 0 | |a Christine Tran |e author |
| 700 | 1 | 0 | |a Mouad Alami |e author |
| 700 | 1 | 0 | |a Abdallah Hamze |e author |
| 700 | 1 | 0 | |a Olivier Provot |e author |
| 245 | 0 | 0 | |a Synthesis and Biological Activities of Pyrazino[1,2-<i>a</i>]indole and Pyrazino[1,2-<i>a</i>]indol-1-one Derivatives |
| 260 | |b MDPI AG, |c 2021-08-01T00:00:00Z. | ||
| 500 | |a 10.3390/ph14080779 | ||
| 500 | |a 1424-8247 | ||
| 520 | |a This review concerns the synthesis and biological activities of pyrazino[1,2-<i>a</i>]indoles and pyrazino[1,2-<i>a</i>]indol-1-ones reported since 1997 and the discovery of biological activity of pyrazinoindole derivatives. In the first part, we first presented the synthetic routes that have been reported from a methodological point of view to access the pyrazinoindole unit according to cyclization reactions using or not using metal catalysts. Then, syntheses and neuropsychiatric, auto-immune, anti-infectious and anti-cancer properties of pyrazinoindoles were detailed. In the second part, we first reported the main accesses to pyrazinoindol-1-one substrates according to Michael reactions, metal-catalyzed and metal-free cyclization reactions. The syntheses and anti-cancer, anti-infectious, anti-allergenic and neuropsychiatric properties of pyrazinoindolones were next described and discussed. | ||
| 546 | |a EN | ||
| 690 | |a pyrazinoindole | ||
| 690 | |a pyrazinoindolone | ||
| 690 | |a cyclization | ||
| 690 | |a catalysis | ||
| 690 | |a biological activity | ||
| 690 | |a Medicine | ||
| 690 | |a R | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Pharmaceuticals, Vol 14, Iss 8, p 779 (2021) | |
| 787 | 0 | |n https://www.mdpi.com/1424-8247/14/8/779 | |
| 787 | 0 | |n https://doaj.org/toc/1424-8247 | |
| 856 | 4 | 1 | |u https://doaj.org/article/eb6bde94853b4f2c9e4dd6b5c8f6fede |z Connect to this object online. |