The Effect of Lamotrigine on Nav1.4 Voltage-Gated Sodium Channels
Lamotrigine (LTG) is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder and it has been known that LTG targets voltage-dependent sodium channels (VGSCs). In this study, we investigated the effect of LTG on the Nav1.4 Na+ current using HEK293 cells expressing mouse Nav1.4 V...
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Elsevier,
2013-01-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_eb6c65f1480c450cbebc45aed6f79c08 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Yoshihiko Nakatani |e author |
| 700 | 1 | 0 | |a Haruka Masuko |e author |
| 700 | 1 | 0 | |a Taku Amano |e author |
| 245 | 0 | 0 | |a The Effect of Lamotrigine on Nav1.4 Voltage-Gated Sodium Channels |
| 260 | |b Elsevier, |c 2013-01-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1254/jphs.13116SC | ||
| 520 | |a Lamotrigine (LTG) is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder and it has been known that LTG targets voltage-dependent sodium channels (VGSCs). In this study, we investigated the effect of LTG on the Nav1.4 Na+ current using HEK293 cells expressing mouse Nav1.4 VGSCs. By the treatment of LTG, Nav1.4 Na+ current was inhibited in a dose-dependent manner. Moreover, 100 μM LTG decreased Nav1.4 Na+ current around 40% and shifted the V1/2 of the inactivation curve to the hyperpolarization side by 20.96 mV. These findings suggest that LTG inhibits Nav1.4 Na+ current and modifies the kinetics of the inactivated state. Keywords:: lamotrigine, Nav1.4, voltage-clamp | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 123, Iss 2, Pp 203-206 (2013) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861319302725 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/eb6c65f1480c450cbebc45aed6f79c08 |z Connect to this object online. |