Mitophagy Mediates the Beige to White Transition of Human Primary Subcutaneous Adipocytes Ex Vivo

• Main Authors: Attila Vámos (Author), Abhirup Shaw (Author), Klára Varga (Author), István Csomós (Author), Gábor Mocsár (Author), Zoltán Balajthy (Author), Cecília Lányi (Author), Zsolt Bacso (Author), Mária Szatmári-Tóth (Author), Endre Kristóf (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Brown and beige adipocytes have multilocular lipid droplets, express uncoupling protein (UCP) 1, and promote energy expenditure. In rodents, when the stimulus of browning subsides, parkin-dependent mitophagy is activated and dormant beige adipocytes persist. In humans, however, the molecular events...