Physiologically‐Based Pharmacokinetic Modeling of the Drug-Drug Interaction of the UGT Substrate Ertugliflozin Following Co‐Administration with the UGT Inhibitor Mefenamic Acid

• المؤلفون الرئيسيون: Ernesto Callegari (مؤلف), Jian Lin (مؤلف), Susanna Tse (مؤلف), Theunis C. Goosen (مؤلف), Vaishali Sahasrabudhe (مؤلف)
• التنسيق: كتاب
• منشور في: Wiley, 2021-02-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

The sodium‐glucose cotransporter 2 inhibitor ertugliflozin is metabolized by the uridine 5'‐diphospho‐glucuronosyltransferase (UGT) isozymes UGT1A9 and UGT2B4/2B7. This analysis evaluated the drug-drug interaction (DDI) following co‐administration of ertugliflozin with the UGT inhibitor mefenam...