Physiologically‐Based Pharmacokinetic Modeling of the Drug-Drug Interaction of the UGT Substrate Ertugliflozin Following Co‐Administration with the UGT Inhibitor Mefenamic Acid

• প্রধান লেখক: Ernesto Callegari (লেখক), Jian Lin (লেখক), Susanna Tse (লেখক), Theunis C. Goosen (লেখক), Vaishali Sahasrabudhe (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Wiley, 2021-02-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

The sodium‐glucose cotransporter 2 inhibitor ertugliflozin is metabolized by the uridine 5'‐diphospho‐glucuronosyltransferase (UGT) isozymes UGT1A9 and UGT2B4/2B7. This analysis evaluated the drug-drug interaction (DDI) following co‐administration of ertugliflozin with the UGT inhibitor mefenam...