Physiologically‐Based Pharmacokinetic Modeling of the Drug-Drug Interaction of the UGT Substrate Ertugliflozin Following Co‐Administration with the UGT Inhibitor Mefenamic Acid

• Κύριοι συγγραφείς: Ernesto Callegari (Συγγραφέας), Jian Lin (Συγγραφέας), Susanna Tse (Συγγραφέας), Theunis C. Goosen (Συγγραφέας), Vaishali Sahasrabudhe (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Wiley, 2021-02-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

The sodium‐glucose cotransporter 2 inhibitor ertugliflozin is metabolized by the uridine 5'‐diphospho‐glucuronosyltransferase (UGT) isozymes UGT1A9 and UGT2B4/2B7. This analysis evaluated the drug-drug interaction (DDI) following co‐administration of ertugliflozin with the UGT inhibitor mefenam...