Physiologically‐Based Pharmacokinetic Modeling of the Drug-Drug Interaction of the UGT Substrate Ertugliflozin Following Co‐Administration with the UGT Inhibitor Mefenamic Acid

The sodium‐glucose cotransporter 2 inhibitor ertugliflozin is metabolized by the uridine 5'‐diphospho‐glucuronosyltransferase (UGT) isozymes UGT1A9 and UGT2B4/2B7. This analysis evaluated the drug-drug interaction (DDI) following co‐administration of ertugliflozin with the UGT inhibitor mefenam...

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Autores principales: Ernesto Callegari (Autor), Jian Lin (Autor), Susanna Tse (Autor), Theunis C. Goosen (Autor), Vaishali Sahasrabudhe (Autor)
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Publicado: Wiley, 2021-02-01T00:00:00Z.
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