Physiologically‐Based Pharmacokinetic Modeling of the Drug-Drug Interaction of the UGT Substrate Ertugliflozin Following Co‐Administration with the UGT Inhibitor Mefenamic Acid

• Ngā kaituhi matua: Ernesto Callegari (Author), Jian Lin (Author), Susanna Tse (Author), Theunis C. Goosen (Author), Vaishali Sahasrabudhe (Author)
• Hōputu: Pukapuka
• I whakaputaina: Wiley, 2021-02-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

The sodium‐glucose cotransporter 2 inhibitor ertugliflozin is metabolized by the uridine 5'‐diphospho‐glucuronosyltransferase (UGT) isozymes UGT1A9 and UGT2B4/2B7. This analysis evaluated the drug-drug interaction (DDI) following co‐administration of ertugliflozin with the UGT inhibitor mefenam...