Paternal age predicts live birth in women above 40 years of age undergoing in-vitro fertilization (IVF)
Purpose: To determine which factors predict pregnancy outcome in women aged 40 years and above who underwent in-vitro fertilization. Method: We conducted a retrospective case-control study of 631 women aged 40-46 years, who underwent a total of 904 IVF cycles with autologous gametes. We used stepwis...
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2021-04-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_ebae6d9f2a8440eca50d7b374fcea1c0 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Guy Shrem |e author |
| 700 | 1 | 0 | |a Nouf M. Alasmari |e author |
| 700 | 1 | 0 | |a Jacques Balayla |e author |
| 700 | 1 | 0 | |a Alexander Volodarsky-Perel |e author |
| 700 | 1 | 0 | |a Weon-Young Son |e author |
| 700 | 1 | 0 | |a Michael H. Dahan |e author |
| 245 | 0 | 0 | |a Paternal age predicts live birth in women above 40 years of age undergoing in-vitro fertilization (IVF) |
| 260 | |b IMR Press, |c 2021-04-01T00:00:00Z. | ||
| 500 | |a 0390-6663 | ||
| 500 | |a 10.31083/j.ceog.2021.02.2275 | ||
| 520 | |a Purpose: To determine which factors predict pregnancy outcome in women aged 40 years and above who underwent in-vitro fertilization. Method: We conducted a retrospective case-control study of 631 women aged 40-46 years, who underwent a total of 904 IVF cycles with autologous gametes. We used stepwise logistic regression analysis to develop predictors of pregnancy, clinical pregnancy and live birth outcomes. Data are presented as mean ± SD, percentage and confidence intervals. Results: Predictors of live birth included maternal (95% CI: 0.36-0.78) and paternal (95% CI: 0.62-0.94) age, the number of follicels > 14 mm (95% CI: 1.2-3.2), the number of oocytes collected (95% CI: 1.3-2.9) the number of metaphase II oocytes (95% CI: 1.3-2.4) and the number of cleavage stage embryos (95% CI: 1.8-2.6). The predictors of pregnancy and clinical pregnancy were similar but did not include male age (P > 0.05). To further determine the role of male age in live birth a control group of women younger than 40 years was collected. Male age was not a significant predictor of live birth among younger women (P = 0.42). Conclusions: Female age and better ovarian stimulation were confirmed as predictors of outcomes in older women doing IVF. However, male age was also noted to be a significant individual predictor of live birth in women over 40 years of age, but not in younger women doing IVF. | ||
| 546 | |a EN | ||
| 690 | |a advanced maternal age | ||
| 690 | |a advanced paternal age | ||
| 690 | |a biologic clock | ||
| 690 | |a ivf | ||
| 690 | |a in-vitro fertilization | ||
| 690 | |a Gynecology and obstetrics | ||
| 690 | |a RG1-991 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Clinical and Experimental Obstetrics & Gynecology, Vol 48, Iss 2, Pp 299-306 (2021) | |
| 787 | 0 | |n https://www.imrpress.com/journal/CEOG/48/2/10.31083/j.ceog.2021.02.2275 | |
| 787 | 0 | |n https://doaj.org/toc/0390-6663 | |
| 856 | 4 | 1 | |u https://doaj.org/article/ebae6d9f2a8440eca50d7b374fcea1c0 |z Connect to this object online. |