Long-term Outcome of Severe Preeclampsia Cases: Cross - Sectional Study

• Main Authors: Yuditiya Purwosunu (Author), Nurida M. Siagian (Author)
• Format: Book
• Published: Indonesian Society of Obstetrics and Gynecology, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Objectives: To investigate the long term outcome of severe preeclampsia mother by clinically and laboratory, and the long  term outcome of the baby that she delivered. Method: This is a cross sectional study was conducted at Obstetrics Outpatient Clinic Dr. Cipto Mangunkusumo General Hospital (Cipto Mangunkusumo NCGH) on January-June 2017, of patients with previous severe preeclampsia that gave birth in Cipto Mangunkusumo NCGHon January 2014 - December 2016, and was descriptively analyze using SPSS Statistics 24. Results: One hundred and twenty seven patients were studied, divided into 3 groups of post - delivery time which were 6 months, 12 months, and 24 months. The 6 months' group, mean of blood pressure were 147/92 mmHg (SD 38/SD 39), BMI 29 kg/m2 (SD 6), CRP level 16.6 mg/l (0.3 - 42.60) and urine protein dipstick 1 (0 - 3). The 12 months' group, mean of blood pressure were 112/88 mmHg (SD 12/SD 24), BMI 21s kg/m2 (SD 7), CRP level 12.7 mg/l (3.4 - 15.2) and urine protein dipstick 0 (0 - 3). The 24 months' group, mean blood pressure 154/95 mmHg (SD 45/SD 62), BMI 28.83 kg/m2, CRP level 14,2 mg/l (SD 8.54) and urine protein dipstick 0 (0 - 3). Meanwhile, the long - term outcome of babies that 68% baby were born with preterm condition and mean birth weight were 1943 grams (SD 1245), the 5th minute Apgar score >7 were 63.78%, and only 44.88% baby had normal growth development. Conclusion: The long - term outcome patients with previous severe preeclampsia are blood pressure, BMI, and CRP level still high, and negative urine protein level until 2 years of post - delivery. The long - term outcome of the babies that delivered were on preterm condition and low birth weight, with less than 50% had normal growth and development. Keywords: c-reactive protein, growth and development, proteinuria, post-delivery, severe preeclampsia.   Abstrak Tujuan: Untuk mengetahui keluaran jangka panjang pada pasien ibu PEB dari sudut klinis dan laboratoris, serta keluaran jangka panjang bayi yang dilahirkan. Metode: Penelitian ini menggunakan desain potong lintang terhadap pasien riwayat PEB yang pernah melahirkan di RSUPN Dr. Cipto Mangunkusumo pada bulan Januari 2014-Desember 2016. Subjek diminta datang ke Poli Obstetri RSUPN Dr. Cipto Mangunkusumo pada Januari-Juni 2017 untuk dilakukan pemeriksaan klinis dan laboratoris (CRP dan protein urin), serta dilakukan analisa deskriptif menggunakan SPSS Statistik 24.   Hasil: Sebanyak 127 pasien yang diteliti terbagi dalam 3 kelompok yaitu pasien riwayat PEB pasca persalinan 6 bulan (kelompok I), 12 bulan (kelompok II), dan 24 bulan (kelompok III). Kelompok I didapatkan rerata tekanan darah (TD) 147/92 mmHg (SD 38/SD 39), IMT 29 kg/m2 (SD 6), kadar CRP 16,6 mg/l (0,3 - 42,60) dan protein urin 1 (0 - 3). Kelompok II didapatkan rerata tekanan darah (TD) 112/88 mmHg (SD 12/SD 24), IMT 21 kg/m2 (SD 7), kadar CRP 12,7 mg/l (3,4 - 15,2) dan protein urin 0 (0 - 3). Kelompok III rerata TD 154/95 mmHg (SD 45/SD 62), IMT 28,83 kg/m2, dengan rerata kadar CRP 14,2 mg/l (SD 8,54) dan protein urin 0 (0 - 3). Sedangkan keluaran jangka panjang bayi yang dilahirkan bahwa 68% lahir dengan kondisi preterm dengan rerata berat lahir 1.943 gram (SD 1.245), nilai Apgar menit ke-5 >7 63,78%, dan hanya 44,88% tumbuh - kembang bayi normal. Kesimpulan: Gambaran keluaran jangka panjang pasien riwayat PEB didapatkan tekanan darah, IMT dan kadar CRP masih tinggi, serta protein urin urin negatif setelah 2 tahun pascapersalinan. Keluaran jangka panjang bayi yang dilahirkan mayoritas kondisi preterm dan berat lahir rendah, dengan kurang dari 50% bayi tumbuh - kembang normal. Kata kunci: c- reactive protein, preeklamsia berat, proteinuria, pascapersalinan, tumbuh kembang bayi.

Item Description

2338-6401
2338-7335
10.32771/inajog.v10i1.637