Screening of major hepatotoxic components of Tripterygium wilfordii based on hepatotoxic injury patterns

• Main Authors: Meng Li (Author), Qiong Luo (Author), Xi Chen (Author), Furong Qiu (Author), Yanyan Tao (Author), Xin Sun (Author), Chenghai Liu (Author)
• Format: Book
• Published: BMC, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Tripterygium wilfordii Hook. F. (TwHF), a traditional Chinese medicine, is widely used in the treatment of rheumatoid arthritis. Due to multiorgan toxicity, particularly hepatotoxicity, the application of TwHF is restricted. To clarify the hepatotoxic substances, zebrafish, hepat...