Theoretical Study at the Molecular Mechanics Level of the Interaction of Tetracycline and Chloramphenicol with the Antibiotic Receptors Present in <em>Enterococcus faecalis</em> (Q839F7) and <em>Streptococcus mutans</em> (Q8DS20)

• Main Authors: Rufo Alberto Figueroa-Banda (Author), Kimberly Francis Figueroa-Castellanos (Author), Edith Angelica Chávez-Oblitas (Author), María Elena Guillen-Nuñez (Author), Flor Ayqui-Cueva (Author), Bruno A. Del- (Author), Karen L. Bellido-Vallejo (Author), Badhin Gómez (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

When dental infections occur, various types of antibiotics are used to combat them. The most common antibiotics to be used are tetracycline and chloramphenicol; likewise, the most common bacteria in dental infections are <i>Enterococcus faecalis</i> and <i>Streptococcus mutans</i>. In the present work, we have studied by molecular mechanics methods the interactions of the ribosomal proteins L16 present in <i>Enterococcus faecalis</i> and <i>Streptococcus mutans</i>, identified with UNIPROT code Q839F7 and Q8DS20, respectively. We evaluated the interactions between Q839F7 and Q8DS20 with tetracycline and chloramphenicol antibiotics. We found that the interaction between <i>Enterococcus faecalis</i> (Q839F7) is much more favorable when treated with chloramphenicol. In contrast, the interaction with tetracycline is favored in the case of Q8DS20 present in <i>Streptococcus mutans</i>. This suggests that the treatment should be differentiated depending on the infection level and the presence of some of these bacteria.

Item Description

10.3390/antibiotics11111640
2079-6382