Relationship of Placental and Serum Lipoprotein-Associated Phospholipase A2 Levels with Hypertensive Disorders of Pregnancy

Jing Wang,1 Xing Dong,2 Hong-Yan Wu,1 Wen-Hua Bu,1 Rong Cong,1 Xin Wang,1 Li-Xin Shang,1 Wen Jiang1 1Department of Obstetrics and Gynecology, The Seventh Medical Center of Chinese PLA General Hospital, Beijing, People's Republic of China; 2Department of General Surgery, The First Medical Center...

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Main Authors: Wang J (Author), Dong X (Author), Wu HY (Author), Bu WH (Author), Cong R (Author), Wang X (Author), Shang LX (Author), Jiang W (Author)
Format: Book
Published: Dove Medical Press, 2022-06-01T00:00:00Z.
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100 1 0 |a Wang J  |e author 
700 1 0 |a Dong X  |e author 
700 1 0 |a Wu HY  |e author 
700 1 0 |a Bu WH  |e author 
700 1 0 |a Cong R  |e author 
700 1 0 |a Wang X  |e author 
700 1 0 |a Shang LX  |e author 
700 1 0 |a Jiang W  |e author 
245 0 0 |a Relationship of Placental and Serum Lipoprotein-Associated Phospholipase A2 Levels with Hypertensive Disorders of Pregnancy 
260 |b Dove Medical Press,   |c 2022-06-01T00:00:00Z. 
500 |a 1179-1411 
520 |a Jing Wang,1 Xing Dong,2 Hong-Yan Wu,1 Wen-Hua Bu,1 Rong Cong,1 Xin Wang,1 Li-Xin Shang,1 Wen Jiang1 1Department of Obstetrics and Gynecology, The Seventh Medical Center of Chinese PLA General Hospital, Beijing, People's Republic of China; 2Department of General Surgery, The First Medical Center of Chinese PLA General Hospital, Beijing, People's Republic of ChinaCorrespondence: Wen Jiang, Email jiangwen20110108@163.comBackground: A series of studies has shown that lipoprotein-associated phospholipase A2 (Lp-PLA2) is closely associated with abnormal lipid metabolism and vascular endothelial cell injury, but its role in hypertensive disorders of pregnancy (HDP) remains unclear. This study aims to determine the relationship between placental and serum LP-PLA2 levels and HDP, and to provide a feasible method for predicting HDP.Methods: The placental and serum Lp-PLA2 levels of 63 patients with HDP (20, 25, and 18 cases with gestational hypertension, mild preeclampsia, and severe preeclampsia, respectively) and 20 women with normal pregnancies (control group) were measured via a combination of tissue microarray and immunohistochemistry, real-time quantitative RT-PCR and enzyme-linked immunosorbent assay (ELISA).Results: 1) The gene and protein expression levels of placental LP-PLA2: the HDP group had significantly higher levels than those of the control group (P < 0.05). The mild preeclampsia group had significantly higher levels than those of the control group (P < 0.05); the severe preeclampsia group had significantly higher levels than those of the mild preeclampsia group (P < 0.05). 2) Serum levels of Lp-PLA2: the HDP group had significantly higher levels than those of the control group (P < 0.05). The Lp-PLA2 levels increased gradually with the progression of the HDP; there were significant differences in the four groups using pair-wise comparisons (P < 0.05). 3) Serum levels of LP-PLA2 were positively correlated with placental LP-PLA2 levels in the HDP group (r = 0.435, P < 0.05).Conclusion: Elevated Lp-PLA2 levels may be associated with the occurrence of HDP, and changes of Lp-PLA2 levels in the maternal blood may be regarded as a monitoring indicator for this disease.Keywords: hypertensive disorders of pregnancy, preeclampsia, lipoprotein-associated phospholipase A2, placenta, serum 
546 |a EN 
690 |a hypertensive disorders of pregnancy 
690 |a preeclampsia 
690 |a lipoprotein-associated phospholipase a2 
690 |a placenta 
690 |a serum 
690 |a Gynecology and obstetrics 
690 |a RG1-991 
655 7 |a article  |2 local 
786 0 |n International Journal of Women's Health, Vol Volume 14, Pp 797-804 (2022) 
787 0 |n https://www.dovepress.com/relationship-of-placental-and-serum-lipoprotein-associated-phospholipa-peer-reviewed-fulltext-article-IJWH 
787 0 |n https://doaj.org/toc/1179-1411 
856 4 1 |u https://doaj.org/article/ec86a4dd2a134f2bb55816d2cb4cff8c  |z Connect to this object online.