Design, Synthesis, In Vitro, and In Silico Studies of New <i>N</i>⁵-Substituted-pyrazolo[3,4-<i>d</i>]pyrimidinone Derivatives as Anticancer CDK2 Inhibitors

• Main Authors: Waheed A. Zaki (Author), Selwan M. El-Sayed (Author), Mohamed Alswah (Author), Ahmed El-Morsy (Author), Ashraf H. Bayoumi (Author), Abrahman S. Mayhoub (Author), Walaa H. Moustafa (Author), Aeshah A. Awaji (Author), Eun Joo Roh (Author), Ahmed H.E. Hassan (Author), Kazem Mahmoud (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CDK2 is a key player in cell cycle processes. It has a crucial role in the progression of various cancers. Hepatocellular carcinoma (HCC) and colorectal cancer (CRC) are two common cancers that affect humans worldwide. The available therapeutic options suffer from many drawbacks including high toxic...