Estimation of daily sodium and potassium excretion from overnight urine of Japanese children and adolescents

Abstract Background Estimates of daily sodium (Na) and potassium (K) excretion were explicitly biased when using equations for adults. We aimed to develop equations to estimate them using overnight urine from Japanese children and adolescents. Methods The subjects comprised 70 students aged 10.49-15...

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Main Authors: Masayuki Okuda (Author), Keiko Asakura (Author), Satoshi Sasaki (Author)
Format: Book
Published: Komiyama Printing Co. Ltd, 2020-11-01T00:00:00Z.
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LEADER 00000 am a22000003u 4500
001 doaj_ec9bed6368f34650a1719e37263e89f5
042 |a dc 
100 1 0 |a Masayuki Okuda  |e author 
700 1 0 |a Keiko Asakura  |e author 
700 1 0 |a Satoshi Sasaki  |e author 
245 0 0 |a Estimation of daily sodium and potassium excretion from overnight urine of Japanese children and adolescents 
260 |b Komiyama Printing Co. Ltd,   |c 2020-11-01T00:00:00Z. 
500 |a 10.1186/s12199-020-00911-3 
500 |a 1342-078X 
500 |a 1347-4715 
520 |a Abstract Background Estimates of daily sodium (Na) and potassium (K) excretion were explicitly biased when using equations for adults. We aimed to develop equations to estimate them using overnight urine from Japanese children and adolescents. Methods The subjects comprised 70 students aged 10.49-15.76 years: validation group, n = 34; and verification group, n = 36. Each subject performed two operations of overnight spot urine (U m) and 24-h urine (U24) sampling. Concentrations of Na, K, and creatinine (Cr) were measured, and anthropometrics were recorded. In the validation group, Na/Cr, and K/Cr (mEq L−1/mg dL−1) in 24-h urine were predicted from their correspondents in overnight urine. Daily Cr excretion (EstCr24; mg d−1) was estimated according to Mage's method. Results In validation, we formulated Na excretion (mg d−1) = 23 × exp (0.2085) × [(Na/CrUm + 1)1.0148 − 1] × 1.078 × EstCr24/10; and K excretion (mg d−1) = 39 × exp (0.0315) × [(K/CrUm + 1)1.3165 − 1] × 1.078 × EstCr24/10. For verification, we compared estimates with the measured 24-h Na excretion 3596 ± 1058 mg d−1, and K excretion 1743 ± 569 mg d−1. The mean biases and intraclass correlations (3, 1) were −131 mg d−1 and 0.60, respectively for Na excretion; and −152 mg d−1 and 0.55 for K excretion. Conclusion We obtained validated equations to estimate daily Na and K excretion with accessible variables such as Na, K, and Cr concentrations of overnight urine, body height and weight, and age for children and adolescents. When using the obtained equations, caution should be paid to small but definite biases and measurement errors. 
546 |a EN 
690 |a Adolescents 
690 |a Children 
690 |a Creatinine 
690 |a Estimation 
690 |a Excretion 
690 |a Potassium 
690 |a Public aspects of medicine 
690 |a RA1-1270 
655 7 |a article  |2 local 
786 0 |n Environmental Health and Preventive Medicine, Vol 25, Iss 1, Pp 1-6 (2020) 
787 0 |n https://doi.org/10.1186/s12199-020-00911-3 
787 0 |n https://doaj.org/toc/1342-078X 
787 0 |n https://doaj.org/toc/1347-4715 
856 4 1 |u https://doaj.org/article/ec9bed6368f34650a1719e37263e89f5  |z Connect to this object online.