SYNTHESES AND ANTIOXIDANT ACTIVITIES OF SOME HYDROXY DIMETHOXY CHALCONE DERIVATIVES
Four (4) hydroxy dimethoxy chalcones derivatives were synthesized by Claisen-Schmidt condensation of hydroxyacetophenone with 3,4-dimethoxybenzaldehyde using conventional method and grinding technique. The synthesized compounds were characterized by spectroscopy (IR, 1H-NMR and 13C-NMR). Synthesis o...
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| Main Authors: | , , , , |
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| Format: | Book |
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Universitas Gadjah Mada,
2014-01-01T00:00:00Z.
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| Summary: | Four (4) hydroxy dimethoxy chalcones derivatives were synthesized by Claisen-Schmidt condensation of hydroxyacetophenone with 3,4-dimethoxybenzaldehyde using conventional method and grinding technique. The synthesized compounds were characterized by spectroscopy (IR, 1H-NMR and 13C-NMR). Synthesis of the hydroxy dimethoxy chalcone using grinding method is better than the conventional method. The synthesis using grinding method require a low concentration base, shorter reaction (15min) and higher yield (70-84%). The antioxidant activity of the compounds was determined by DPPH method, showed that 2',5'-dihydroxy-3,4-dimethoxy chalcone have the highest antioxidant activity. |
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| Item Description: | 10.14499/indonesianjpharm25iss1pp17 2338-9427 2338-9486 |