Exploring inter-ethnic and inter-patient variability and optimal dosing of osimertinib: a physiologically based pharmacokinetic modeling approach
Purpose: This study aimed to develop and validate a physiologically based pharmacokinetic (PBPK) model for osimertinib (OSI) to predict plasma trough concentration (Ctrough) and pulmonary EGFRm+ (T790M and L858R mutants) inhibition in Caucasian, Japanese, and Chinese populations. The PBPK model was...
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| Main Authors: | , , , |
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| Format: | Book |
| Published: |
Frontiers Media S.A.,
2024-03-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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