Exploring inter-ethnic and inter-patient variability and optimal dosing of osimertinib: a physiologically based pharmacokinetic modeling approach

• Main Authors: Feng Liang (Author), Yimei Zhang (Author), Qian Xue (Author), Na Yao (Author)
• 格式: 圖書
• 出版: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Purpose: This study aimed to develop and validate a physiologically based pharmacokinetic (PBPK) model for osimertinib (OSI) to predict plasma trough concentration (Ctrough) and pulmonary EGFRm+ (T790M and L858R mutants) inhibition in Caucasian, Japanese, and Chinese populations. The PBPK model was...