Methoxy and bromo scans on N-(5-methoxyphenyl) methoxybenzenesulphonamides reveal potent cytotoxic compounds, especially against the human breast adenocarcinoma MCF7 cell line

• Hlavní autoři: Myriam González (Autor), María Ovejero-Sánchez (Autor), Alba Vicente-Blázquez (Autor), Manuel Medarde (Autor), Rogelio González-Sarmiento (Autor), Rafael Peláez (Autor)
• Médium: Kniha
• Vydáno: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Thirty seven N-(5-methoxyphenyl)-4-methoxybenzenesulphonamide with methoxy or/and bromo substitutions (series 1-4) and with different substituents on the sulphonamide nitrogen have been synthesised. 21 showed sub-micromolar cytotoxicity against HeLa and HT-29 human tumour cell lines, and were partic...