Methoxy and bromo scans on N-(5-methoxyphenyl) methoxybenzenesulphonamides reveal potent cytotoxic compounds, especially against the human breast adenocarcinoma MCF7 cell line

• Main Authors: Myriam González (Author), María Ovejero-Sánchez (Author), Alba Vicente-Blázquez (Author), Manuel Medarde (Author), Rogelio González-Sarmiento (Author), Rafael Peláez (Author)
• Formato: Libro
• Publicado: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Thirty seven N-(5-methoxyphenyl)-4-methoxybenzenesulphonamide with methoxy or/and bromo substitutions (series 1-4) and with different substituents on the sulphonamide nitrogen have been synthesised. 21 showed sub-micromolar cytotoxicity against HeLa and HT-29 human tumour cell lines, and were partic...