Relapse of Neonatal <i>Escherichia coli</i> Meningitis: Did We Miss Something at First?
Relapse of neonatal meningitis is most commonly caused by <i>Escherichia coli</i>. Management to prevent relapse varies and evidence is limited. We present four cases of relapsing neonatal <i>E. coli</i> meningitis in Denmark in 2016-2017 and review the current literature on...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Book |
| Published: |
MDPI AG,
2021-02-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Relapse of neonatal meningitis is most commonly caused by <i>Escherichia coli</i>. Management to prevent relapse varies and evidence is limited. We present four cases of relapsing neonatal <i>E. coli</i> meningitis in Denmark in 2016-2017 and review the current literature on this subject. During the primary episodes, our patients received cephalosporin for 3 weeks and gentamicin for the first 3 days. The only identified risk factor was delayed CSF sterilization in three of four cases and no repeated lumbar puncture. Relapse occurred after 2-28 days; one case with ventriculitis and one with empyema. Relapses were treated for 6-14 weeks with monotherapy. No children had an underlying disease predisposing to <i>E. coli</i> meningitis. There is generally a trend towards reducing invasive procedures, e.g., lumbar puncture and the length of intravenous antibiotics in pediatric infectious diseases, but our cases highlight a condition where the opposite might be needed. |
|---|---|
| Item Description: | 10.3390/children8020126 2227-9067 |