Influence of Perinatal Factors on Blood Tryptase and Fecal Calprotectin Levels in Newborns

• Main Authors: Justine Paysal (Author), Charlotte Oris (Author), Ugo Troin (Author), Pierre-Nicolas Limeri (Author), Jeanne Allard (Author), Marie Tadrent (Author), Bruno Pereira (Author), Etienne Merlin (Author), Emmanuelle Rochette (Author), Bertrand Evrard (Author), Julie Durif (Author), Vincent Sapin (Author), Maguelonne Pons (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Background: Blood tryptase and fecal calprotectin levels may serve as biomarkers of necrotizing enterocolitis. However, their interpretation may be hindered by the little-known effects of perinatal factors. The aim of this study was to compare the tryptase and calprotectin levels in newborns according to their term, trophicity, and sex. Method: One hundred and fifty-seven premature newborns and 157 full-term newborns were included. Blood tryptase and fecal calprotectin were assayed. Results: Blood tryptase levels were higher in premature than in full-term newborns (6.4 vs. 5.2 µg/L; <i>p</i> < 0.001). In situations of antenatal use of corticosteroids (<i>p</i> = 0.007) and non-exclusive use of human milk (<i>p</i> = 0.02), these levels were also higher. However, in multiple linear regression analyses, only prematurity significantly influenced tryptase levels. Fecal calprotectin levels were extremely wide-ranging and were much higher in female than in male newborns (300.5 vs. 110.5 µg/g; <i>p</i> < 0.001). Conclusions: The differences in tryptase levels according to term could be linked to early aggression of the still-immature digestive wall in premature newborns, in particular, by enteral feeding started early. The unexpected influence of sex on fecal calprotectin levels remains unexplained.

Item Description

10.3390/children10020345
2227-9067