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Merkel Cell Carcinoma Concomitant with Invasive Bowen's Disease: Immunohistochemical Investigation of Tumor-Infiltrating Leukocytes

Merkel cell carcinoma (MCC) is an aggressive, cutaneous, neuroendocrine carcinoma and, in rare cases, occurs with Bowen's disease (BD). In this report, we describe a case of MCC concurrent with invasive BD and compare the profiles of tumor-infiltrating leukocytes in the lesional skin of MCC and...

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Main Authors: Hisayuki Tono (Author), Taku Fujimura (Author), Eimei Iwama (Author), Yoshiyuki Kusakari (Author), Sadanori Furudate (Author), Yumi Kambayashi (Author), Takahiro Haga (Author), Akira Hashimoto (Author), Setsuya Aiba (Author)
Format: Book
Published: Karger Publishers, 2015-01-01T00:00:00Z.
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Summary:Merkel cell carcinoma (MCC) is an aggressive, cutaneous, neuroendocrine carcinoma and, in rare cases, occurs with Bowen's disease (BD). In this report, we describe a case of MCC concurrent with invasive BD and compare the profiles of tumor-infiltrating leukocytes in the lesional skin of MCC and invasive BD. Interestingly, immunohistochemical study revealed significant numbers of CD8+ cells and caspase 3-expressing cells in the same areas of invasive BD and MCC. Our present case suggests that MCC concurrent with invasive BD might have a good prognosis because of the substantial number of CD8+ cells in the tumor.
Item Description:1662-6567
10.1159/000371732

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