Merkel Cell Carcinoma Concomitant with Invasive Bowen's Disease: Immunohistochemical Investigation of Tumor-Infiltrating Leukocytes
Merkel cell carcinoma (MCC) is an aggressive, cutaneous, neuroendocrine carcinoma and, in rare cases, occurs with Bowen's disease (BD). In this report, we describe a case of MCC concurrent with invasive BD and compare the profiles of tumor-infiltrating leukocytes in the lesional skin of MCC and...
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| Main Authors: | , , , , , , , , |
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| Format: | Book |
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Karger Publishers,
2015-01-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_edd2d9b0a9a6428a859171e3f1a17a68 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Hisayuki Tono |e author |
| 700 | 1 | 0 | |a Taku Fujimura |e author |
| 700 | 1 | 0 | |a Eimei Iwama |e author |
| 700 | 1 | 0 | |a Yoshiyuki Kusakari |e author |
| 700 | 1 | 0 | |a Sadanori Furudate |e author |
| 700 | 1 | 0 | |a Yumi Kambayashi |e author |
| 700 | 1 | 0 | |a Takahiro Haga |e author |
| 700 | 1 | 0 | |a Akira Hashimoto |e author |
| 700 | 1 | 0 | |a Setsuya Aiba |e author |
| 245 | 0 | 0 | |a Merkel Cell Carcinoma Concomitant with Invasive Bowen's Disease: Immunohistochemical Investigation of Tumor-Infiltrating Leukocytes |
| 260 | |b Karger Publishers, |c 2015-01-01T00:00:00Z. | ||
| 500 | |a 1662-6567 | ||
| 500 | |a 10.1159/000371732 | ||
| 520 | |a Merkel cell carcinoma (MCC) is an aggressive, cutaneous, neuroendocrine carcinoma and, in rare cases, occurs with Bowen's disease (BD). In this report, we describe a case of MCC concurrent with invasive BD and compare the profiles of tumor-infiltrating leukocytes in the lesional skin of MCC and invasive BD. Interestingly, immunohistochemical study revealed significant numbers of CD8+ cells and caspase 3-expressing cells in the same areas of invasive BD and MCC. Our present case suggests that MCC concurrent with invasive BD might have a good prognosis because of the substantial number of CD8+ cells in the tumor. | ||
| 546 | |a EN | ||
| 690 | |a Invasive Bowenߣs disease | ||
| 690 | |a Merkel cell carcinoma | ||
| 690 | |a Tumor-infiltrating leukocytes | ||
| 690 | |a CD8 | ||
| 690 | |a Caspase 3 | ||
| 690 | |a Dermatology | ||
| 690 | |a RL1-803 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Case Reports in Dermatology, Vol 7, Iss 1, Pp 1-6 (2015) | |
| 787 | 0 | |n http://www.karger.com/Article/FullText/371732 | |
| 787 | 0 | |n https://doaj.org/toc/1662-6567 | |
| 856 | 4 | 1 | |u https://doaj.org/article/edd2d9b0a9a6428a859171e3f1a17a68 |z Connect to this object online. |