Prognosis of ampullary cancer based on immunohistochemical type and expression of osteopontin

• Main Authors: Zhang Wen-zhi (Author), Dong Jia-hong (Author), Zhao Xiang-qian (Author), Liu Zhe (Author)
• Format: Book
• Published: BMC, 2011-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<p>Abstract</p> <p>Background</p> <p>Ampullary cancer (AC) was classified as pancreatobiliary, intestinal, or other subtype based on the expression of cytokeratin 7 (CK7) and cytokeratin 20 (CK20). We aimed to explore the association of AC subtype with patient prognosis.</p> <p>Methods</p> <p>The relationship of AC subtype and expression of Osteopontin (OPN) with the prognosis of 120 AC patients after pancreaticoduodenectomy was investigated.</p> <p>Results</p> <p>The patients had pancreatobiliary (CK7⁺/CK20^-, n = 24, 20%), intestinal (CK7^-/CK20⁺, n = 29, 24.2%) or other (CK7⁺/CK20⁺or CK7^-/CK20^-, n = 67, 55.8%) subtypes of AC, and their median survival times were 23 ± 4.2, 38 ± 2.8 and 64 ± 16.8 months, respectively. The survival times of 64 OPN^-patients (53.3%) and 56 OPN⁺patients (46.7%) were 69 ± 18.4 and 36 ± 1.3 months, respectively. There was no significant effect of AC subtype on survival of OPN^-patients. For OPN⁺patients, those with pancreatobiliary AC had a shorter survival time (22 ± 6.6 months) than those with intestinal AC (37 ± 1.4 months, <it>p </it>= 0.041), and other AC subtype (36 ± 0.9 months, <it>p </it>= 0.010); intestinal and other AC subtypes had similar survival times.</p> <p>Conclusions</p> <p>The prognosis of AC patients can be estimated based on immunohistochemical classification and OPN status.</p>

Item Description

10.1186/1746-1596-6-98
1746-1596