Longitudinal assessment of D-dimer and plasminogen activator inhibitor type-1 plasma levels in pregnant women with risk factors for preeclampsia

• Main Authors: Flávia Campos Lucena (Author), Eura Martins Lage (Author), Patrícia Gonçalves Teixeira (Author), Alexandre Simões Barbosa (Author), Rejane Diniz (Author), Bashir Lwaleed (Author), André Talvani (Author), Patrícia Nessralla Alpoim (Author), Luiza Oliveira Perucci (Author), Luci Maria SantAna Dusse (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Objective: Investigating D-Dimer/D-Di and plasminogen activator inhibitor type-1/PAI-1 levels throughout gestation in women with preeclampsia/PE risk factors. Methods: D-Di and PAI-1 plasma levels were determined in 28 women at 12-19, 20-29, 30-34 and 35-40 weeks of gestation. Results: D-Di was lower at 12-19 weeks and higher at 30-34 weeks in women who developed PE versus who did not develop it. D-Di increased throughout gestation in both groups, peaking earlier in pregnant women who developed PE versus who did not develop it. PA1-1 increased across gestation, but it didn't differ between groups. Conclusion: D-Di was able to discriminate these groups of women at 12-19 and 30-34 weeks of gestation.

Item Description

1064-1955
1525-6065
10.1080/10641955.2019.1577435