Association between anorexia of ageing and sarcopenia among Japanese older adults

Abstract Background Malnutrition plays an essential role in the mechanism of pathogenesis for sarcopenia. In late life, both food consumption and energy intakes decline. One of key factors for reduced energy intakes is anorexia of ageing. The aim of this study is to examine the association between a...

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Main Authors: Kota Tsutsumimoto (Author), Takehiko Doi (Author), Sho Nakakubo (Author), Minji Kim (Author), Satoshi Kurita (Author), Hideaki Ishii (Author), Hiroyuki Shimada (Author)
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Published: Wiley, 2020-10-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Kota Tsutsumimoto  |e author 
700 1 0 |a Takehiko Doi  |e author 
700 1 0 |a Sho Nakakubo  |e author 
700 1 0 |a Minji Kim  |e author 
700 1 0 |a Satoshi Kurita  |e author 
700 1 0 |a Hideaki Ishii  |e author 
700 1 0 |a Hiroyuki Shimada  |e author 
245 0 0 |a Association between anorexia of ageing and sarcopenia among Japanese older adults 
260 |b Wiley,   |c 2020-10-01T00:00:00Z. 
500 |a 2190-6009 
500 |a 2190-5991 
500 |a 10.1002/jcsm.12571 
520 |a Abstract Background Malnutrition plays an essential role in the mechanism of pathogenesis for sarcopenia. In late life, both food consumption and energy intakes decline. One of key factors for reduced energy intakes is anorexia of ageing. The aim of this study is to examine the association between anorexia of ageing and sarcopenia among community‐dwelling elderly Japanese individuals. Methods This uses population‐based, cross‐sectional cohort study of elderly Japanese individuals. Anorexia of ageing was assessed via a simplified nutritional appetite questionnaire. Handgrip strength and walking speed were tested, and skeletal muscle mass was assessed using a bio‐impedance analysis device. Subjects with sarcopenia were defined as those who met the criteria of the Asian Working Group for Sarcopenia. The association between anorexia of ageing and sarcopenia was then analysed via multiple regression analysis. Results In total, 9,496 elderly Japanese individuals were evaluated (mean age 74.1 ± 5.4 years; male, 47.0%). The prevalence of anorexia of ageing was 9.8% (n = 927) in the present study. The prevalence of sarcopenia in men was 1.1%, 1.8%, 6.1%, 10.1%, and 21.2% and was 1.6%, 3.3%, 3.6%, 4.8%, and 7.4% in women aged 65-69, 70-74, 75-79, 80-84, and 85 years and older, respectively. The prevalence of anorexia also showed an age‐dependent increase in both sexes (P < 0.001, respectively). The prevalence of anorexia in men was 8.3%, 6.3%, 9.8%, 13.6%, and 12.9% and was 7.9%, 9.4%, 10.5%, 17.6%, and 17.1% in women aged 65-69, 70-74, 75-79, 80-84, and 85 years and older, respectively. In multivariable logistic regression model adjusted for the covariates except for albumin, anorexia of ageing was independently associated with sarcopenia (OR: 1.45, 95% CI: 1.07 to 1.95; P = 0.015). This significant association remained even after adjusting for all covariates including nutritional status (OR: 1.42, 95% CI: 1.06 to 1.92, P = 0.020). Conclusions Anorexia of ageing is associated with sarcopenia among Japanese elderly individuals. Further studies are needed to determine whether a causal association exists between anorexia and sarcopenia. 
546 |a EN 
690 |a Anorexia of ageing 
690 |a Sarcopenia 
690 |a Older people 
690 |a Diseases of the musculoskeletal system 
690 |a RC925-935 
690 |a Human anatomy 
690 |a QM1-695 
655 7 |a article  |2 local 
786 0 |n Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 5, Pp 1250-1257 (2020) 
787 0 |n https://doi.org/10.1002/jcsm.12571 
787 0 |n https://doaj.org/toc/2190-5991 
787 0 |n https://doaj.org/toc/2190-6009 
856 4 1 |u https://doaj.org/article/edf1cc7f4d8b41e18d4987bb5a60fa4a  |z Connect to this object online.