Induction of CD4(+)CD25(+)FOXP3(+) regulatory T cells during human hookworm infection modulates antigen-mediated lymphocyte proliferation.

• Main Authors: Natasha Delaqua Ricci (Author), Jacqueline Araújo Fiúza (Author), Lilian Lacerda Bueno (Author), Guilherme Grossi Lopes Cançado (Author), Pedro Henrique Gazzinelli-Guimarães (Author), Virgillio Gandra Martins (Author), Leonardo Ferreira Matoso (Author), Rodrigo Rodrigues Cambraia de Miranda (Author), Stefan Michael Geiger (Author), Rodrigo Correa-Oliveira (Author), Andréa Gazzinelli (Author), Daniella Castanheira Bartholomeu (Author), Ricardo Toshio Fujiwara (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hookworm infection is considered one of the most important poverty-promoting neglected tropical diseases, infecting 576 to 740 million people worldwide, especially in the tropics and subtropics. These blood-feeding nematodes have a remarkable ability to downmodulate the host immune response, protect...