Serum Predose Metabolic Profiling for Prediction of Rosuvastatin Pharmacokinetic Parameters in Healthy Volunteers

• Main Authors: Anne Michelli Reis Silveira (Author), Gustavo Henrique Bueno Duarte (Author), Anna Maria Alves de Piloto Fernandes (Author), Pedro Henrique Dias Garcia (Author), Nelson Rogerio Vieira (Author), Marcia Aparecida Antonio (Author), Patricia de Oliveira Carvalho (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rosuvastatin is a well-known lipid-lowering agent generally used for hypercholesterolemia treatment and coronary artery disease prevention. There is a substantial inter-individual variability in the absorption of statins usually caused by genetic polymorphisms leading to a variation in the correspon...