Diagnostic Performance of Multiple Sound Touch Elastography for Differentiating Benign and Malignant Thyroid Nodules
This study evaluated the ability of Sound Touch Elastography (STE) to distinguish malignant from benign thyroid nodules by quantifying tumor stiffness using the elastic ratio (EI) and shear modulus (G). Eighty-six patients with 86 nodules were enrolled in this study. There were 24/86 (27.90%) thyroi...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Book |
| Published: |
Frontiers Media S.A.,
2018-11-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_ee72fedbf74a4a78b8fe1ed5cb451e8c | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Lei Zhang |e author |
| 700 | 1 | 0 | |a Lei Zhang |e author |
| 700 | 1 | 0 | |a Zhimin Ding |e author |
| 700 | 1 | 0 | |a Zhimin Ding |e author |
| 700 | 1 | 0 | |a Fajin Dong |e author |
| 700 | 1 | 0 | |a Fajin Dong |e author |
| 700 | 1 | 0 | |a Fajin Dong |e author |
| 700 | 1 | 0 | |a Huaiyu Wu |e author |
| 700 | 1 | 0 | |a Huaiyu Wu |e author |
| 700 | 1 | 0 | |a Weiyu Liang |e author |
| 700 | 1 | 0 | |a Weiyu Liang |e author |
| 700 | 1 | 0 | |a Hongtian Tian |e author |
| 700 | 1 | 0 | |a Hongtian Tian |e author |
| 700 | 1 | 0 | |a Xiuqin Ye |e author |
| 700 | 1 | 0 | |a Xiuqin Ye |e author |
| 700 | 1 | 0 | |a Hui Luo |e author |
| 700 | 1 | 0 | |a Hui Luo |e author |
| 700 | 1 | 0 | |a Jinfeng Xu |e author |
| 700 | 1 | 0 | |a Jinfeng Xu |e author |
| 245 | 0 | 0 | |a Diagnostic Performance of Multiple Sound Touch Elastography for Differentiating Benign and Malignant Thyroid Nodules |
| 260 | |b Frontiers Media S.A., |c 2018-11-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2018.01359 | ||
| 520 | |a This study evaluated the ability of Sound Touch Elastography (STE) to distinguish malignant from benign thyroid nodules by quantifying tumor stiffness using the elastic ratio (EI) and shear modulus (G). Eighty-six patients with 86 nodules were enrolled in this study. There were 24/86 (27.90%) thyroid papillary carcinomas (TPC) and 62/86 (72.10%) benign nodules. The mean EI was significantly lower in TPCs than in benign nodules. The EI area under the receiver operating characteristic curve (ROC) was 80%. The EI cutoff value for TPCs was 0.215%. The sensitivity (Sen), specificity (Spe), positive likelihood ratio (LR+), and negative likelihood ratio (LR-) were 71%, 73%, 2.58, and 0.40, respectively. Gmax, Gmean, and Gsd were significantly higher in TPCs than in benign nodules. There were no significant differences in Gmin. Compared with other G parameters, Gmax with an optimal cutoff value of 15.82 kPa had the highest AUROC value (84%). The Sen, Spe, LR+, and LR- were 79.17%, 79.03%, 3.776, and 0.261, respectively. We pooled the EI, Gmax, Gmean, and Gsd and the pooled-Sen, Spe, LR+, LR-, diagnostic odds ratio and odds ratio, and area under the summary ROC were 79%, 71%, 2.73, 0.29, 2.23, 9.29, and 82%, respectively. STE could be a new ultrasound diagnostic method for evaluating benign and malignant thyroid nodules. | ||
| 546 | |a EN | ||
| 690 | |a Sound Touch Elastography | ||
| 690 | |a thyroid cancer | ||
| 690 | |a shear modulus | ||
| 690 | |a summary receiver operating characteristic curve | ||
| 690 | |a diagnosis | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 9 (2018) | |
| 787 | 0 | |n https://www.frontiersin.org/article/10.3389/fphar.2018.01359/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/ee72fedbf74a4a78b8fe1ed5cb451e8c |z Connect to this object online. |