Association of GSTP1 Ile-105-Val Gene Polymorphism with Response to Treatment Among Iraqi Chronic Myeloid Leukaemia Patients

Background: Pharmacogenomics is a relatively new study field that synergize pharmacology with genomics, analyzing the correlation between genetic variation and pharmacokinetics among patients. In the current study, we evaluated the potential effect of functional polymorphisms within gene encoding fo...

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Main Authors: Atyab Abdul Hameed Alaqidi (Author), Maysem Mouayad Alwash (Author)
Format: Book
Published: College of Pharmacy / Mustansiriyah University, 2018-12-01T00:00:00Z.
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001 doaj_eebfb34f455845889d1d9fda2ba5e0a9
042 |a dc 
100 1 0 |a Atyab Abdul Hameed Alaqidi  |e author 
700 1 0 |a Maysem Mouayad Alwash  |e author 
245 0 0 |a Association of GSTP1 Ile-105-Val Gene Polymorphism with Response to Treatment Among Iraqi Chronic Myeloid Leukaemia Patients 
260 |b College of Pharmacy / Mustansiriyah University,   |c 2018-12-01T00:00:00Z. 
500 |a 10.32947/ajps.v18i2.487 
500 |a 1815-0993 
500 |a 2959-183X 
520 |a Background: Pharmacogenomics is a relatively new study field that synergize pharmacology with genomics, analyzing the correlation between genetic variation and pharmacokinetics among patients. In the current study, we evaluated the potential effect of functional polymorphisms within gene encoding for Glutathione S transferase pi class (GSTPs) and treatment response among chronic myeloid leukaemia) CML) patients. GSTPs are multifunctional phase II biotransformation enzymes. Their main biologic role is to catalyze the conjugation to endogenous glutathione (GSH). In addition, they can alter drug potency in malignant cells. Polymorphic variants of these enzymes have been implicated in inter-patients' variability in drug response and outcome in CML patients. Aim of study: Evaluating the association between GSTP1 Ile-105-Val gene polymorphism and response to treatment among Iraqi CML patients.  Method: A 'PCR-RFLP' assay was implemented to detect the polymorphic variants of codon 105 GSTP1 gene of forty Iraqi CML patients in chronic phase referring to the National Center of Haematology in the period between November 2017 and July 2018. Results: Our result revealed a statistically significant association between the GSTP1 genotypes and response to treatment. The variant genotypes were associated with inferior log reduction in BCR-ABL1 mRNA and poorer responses comparing to the wild genotype with P-value of 0.006, and 0.034 respectively. 
546 |a EN 
690 |a GSTPs, Chronic Myeloid Leukaemia, Polymorphism, Response. 
690 |a Pharmacy and materia medica 
690 |a RS1-441 
655 7 |a article  |2 local 
786 0 |n Al-Mustansiriyah Journal of Pharmaceutical Sciences, Vol 18, Iss 2 (2018) 
787 0 |n https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/487 
787 0 |n https://doaj.org/toc/1815-0993 
787 0 |n https://doaj.org/toc/2959-183X 
856 4 1 |u https://doaj.org/article/eebfb34f455845889d1d9fda2ba5e0a9  |z Connect to this object online.