Characterization of the Ca2+-gated and voltage-dependent K+-channel Slo-1 of nematodes and its interaction with emodepside.

• Main Authors: Daniel Kulke (Author), Georg von Samson-Himmelstjerna (Author), Sandra M Miltsch (Author), Adrian J Wolstenholme (Author), Aaron R Jex (Author), Robin B Gasser (Author), Cristina Ballesteros (Author), Timothy G Geary (Author), Jennifer Keiser (Author), Simon Townson (Author), Achim Harder (Author), Jürgen Krücken (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The cyclooctadepsipeptide emodepside and its parent compound PF1022A are broad-spectrum nematicidal drugs which are able to eliminate nematodes resistant to other anthelmintics. The mode of action of cyclooctadepsipeptides is only partially understood, but involves the latrophilin Lat-1 receptor and...