Tumor Necrosis Factor-Alpha and Age-Related Pathologies

• Main Author: S. V. Topolyanskaya (Author)
• Format: Book
• Published: SINAPS LLC, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2226-6704; 2411-6564; 10.20514/2226-6704-2020-10-6-414-421
• Keywords: inflammation; cytokines; tumor necrosis factor-α (tnf-α); atherosclerosis; aging; old age; long-livers; Internal medicine; RC31-1245
• Source: Архивъ внутренней медицины, Vol 10, Iss 6, Pp 414-421 (2020)

Modern concepts about the «inflammaging» and the role of subclinical inflammation in various age-associated pathology are described in the review. Particular attention is paid to the tumor necrosis factor-α, a key cytokine that plays an important role in the pathogenesis of chronic inflammatory diseases as well as in aging. The increased levels of tumor necrosis factor-α leads to the onset and progression of various diseases, to severity of frailty, to disability and mortality of elderly persons. Tumor necrosis factor-α affects different risk factors for cardiovascular diseases, contributes to the onset and progression of atherosclerosis and related pathology. This cytokine can also aggravate various metabolic disorders, mainly - insulin resistance and diabetes mellitus. Tumor necrosis factor-α is a key cytokine that stimulates bone resorption (up to osteoporosis) and sarcopenia (up to cachexia). Currently available data confirm the important role of tumor necrosis factor-α in various age-associated disorders.