N-Alkyl-Substituted Isatins Enhance P2X7 Receptor-Induced Interleukin-1β Release from Murine Macrophages

Extracellular adenosine 5'-triphosphate (ATP) activates the P2X7 receptor channel to induce the rapid release of the proinflammatory cytokine, interleukin- (IL-) 1β, from macrophages. Microtubule rearrangements are thought to be involved in this process. Some isatin derivatives alter microtubul...

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Bibliographic Details
Main Authors: Ronald Sluyter (Author), Kara L. Vine (Author)
Format: Book
Published: Hindawi Limited, 2016-01-01T00:00:00Z.
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