Hybrid inhibitors of DNA and HDACs remarkably enhance cytotoxicity in leukaemia cells

• Main Authors: Yoojin Song (Author), Sun You Park (Author), Zhexue Wu (Author), Kwang-Hyeon Liu (Author), Young Ho Seo (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chlorambucil is a nitrogen mustard-based DNA alkylating drug, which is widely used as a front-line treatment of chronic lymphocytic leukaemia (CLL). Despite its widespread application and success for the initial treatment of leukaemia, a majority of patients eventually develop acquired resistance to...