The Impact of Formulation on Lutein, Zeaxanthin, and <i>meso</i>-Zeaxanthin Bioavailability: A Randomised Double-Blind Placebo-Controlled Study
Lutein (L), zeaxanthin (Z), and <i>meso</i>-zeaxanthin (MZ) have been the focus of research and commercial interest for their applications in human health. Research into formulations to enhance their bioavailability is merited. This 6 month randomised placebo-controlled trial involving 8...
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| Main Authors: | , , , , , , |
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| Format: | Book |
| Published: |
MDPI AG,
2020-08-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Lutein (L), zeaxanthin (Z), and <i>meso</i>-zeaxanthin (MZ) have been the focus of research and commercial interest for their applications in human health. Research into formulations to enhance their bioavailability is merited. This 6 month randomised placebo-controlled trial involving 81 healthy volunteers compared the bioavailability of different formulations of free L, Z, and MZ in sunflower or omega-3 oil versus L, Z, and MZ diacetates (Ld, Zd, and MZd) in a micromicellar formulation. Fasting serum carotenoids, macular pigment, and skin carotenoid score were analysed at baseline and 6 months. Serum L, Z, and MZ concentrations increased in all active interventions compared to placebo (<i>p</i> < 0.001 to <i>p</i> = 0.008). The diacetate micromicelle formulation exhibited a significantly higher mean response in serum concentrations of Z and MZ compared to the other active interventions (<i>p</i> = 0.002 to 0.019). A micromicellar formulation with solubilised Z and MZ diacetates is a promising technology advancement that enhances the bioavailability of these carotenoids when compared to traditional carotenoid formulations (ISRCTN clinical trial registration number: ISRCTN18206561). |
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| Item Description: | 10.3390/antiox9080767 2076-3921 |