The role of candidate pharmacogenetic variants in determining valproic acid efficacy, toxicity and concentrations in patients with epilepsy

• Main Authors: Hady Yazbeck (Author), Joe Youssef (Author), Wassim Nasreddine (Author), Abdullah El Kurdi (Author), Nathalie Zgheib (Author), Ahmad Beydoun (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

BackgroundAntiseizure medications (ASM) exhibit considerable interindividual variability in terms of efficacy and adverse events. Genetic variation is thought to contribute to these differences in clinical outcomes. Specifically, the response to valproic acid (VPA), a widely used ASM, is influenced...