Relationships between geomagnetic Ар-indeх and parameters of the immunity in patients with multiple sclerosis and radiculopathies

• Main Authors: Igor Popovych (Author), Anatoliy Gozhenko (Author), Nataliya Badiuk (Author), Marek Napierała (Author), Radosław Muszkieta (Author), Walery Zukow (Author), Roman Yanchij (Author), Natalia Lapovets' (Author), Lyubov Lapovets' (Author), Viorica Akimova (Author), Yaryna Nahurna (Author), Olha Martianova (Author), Roman Vivchar (Author), Ivanna Chendey (Author), Sofiya Ruzhylo (Author)
• Format: Book
• Published: Kazimierz Wielki University, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2391-8306; 10.12775/JEHS.2021.11.03.009
• Keywords: geomagnetic ap-index; immune status; multiple sclerosis; radiculopathy.; Education; L; Sports; GV557-1198.995; Medicine; R
• Source: Journal of Education, Health and Sport, Vol 11, Iss 3, Pp 77-90 (2021)

<p class="MsoNormal"><span class="15" style="font-family: 'Times New Roman'; background: #f5f5f5;">Background.</span><span style="font-family: 'Times New Roman'; background: #f5f5f5;"> </span><span class="15" style="font-family: 'Times New Roman'; background: #f5f5f5;">The effect of geomagnetism on human immunity has so far been studied through long-term observations.</span><span style="font-family: 'Times New Roman'; background: #f5f5f5;"> </span><span class="15" style="font-family: 'Times New Roman'; background: #f5f5f5;">We set ourselves the goal of detecting the immediate immunotropic effects of the Earth's magnetic field by analyzing the relationships between immunity parameters and the geomagnetic Ap-index.</span><span style="font-family: 'Times New Roman'; background: #f5f5f5;"> </span><span class="15" style="font-family: 'Times New Roman'; background: #f5f5f5;">Material and methods.</span><span style="font-family: 'Times New Roman'; background: #f5f5f5;"> </span><span class="15" style="font-family: 'Times New Roman'; background: #f5f5f5;">The object of observation were 74 patients with multiple sclerosis and 14 patients with radiculopathies, who in the period from September 2014 to November 2018 conducted a one-time assessment of immune status by the relative content in the blood of lymphocytes of CD3</span>^{<span class="15" style="font-family: 'Times New Roman'; vertical-align: super; background: #f5f5f5;">+</span>}<span style="font-family: 'Times New Roman';">, CD4</span>^{<span style="font-family: 'Times New Roman'; vertical-align: super;">+</span>}<span style="font-family: 'Times New Roman';">, CD8</span>^{<span style="font-family: 'Times New Roman'; vertical-align: super;">+</span>}<span style="font-family: 'Times New Roman';">, CD25</span>^{<span style="font-family: 'Times New Roman'; vertical-align: super;">+</span>}<span style="font-family: 'Times New Roman';">, CD56</span>^{<span style="font-family: 'Times New Roman'; vertical-align: super;">+</span>}<span style="font-family: 'Times New Roman';"> and CD19</span>^{<span style="font-family: 'Times New Roman'; vertical-align: super;">+</span>}<span class="15" style="font-family: 'Times New Roman'; background: #f5f5f5;"> phenotypes</span><span style="font-family: 'Times New Roman';"> and serum level of Immunoglobulines M, G, A as well as CIC and IL-1β. </span><span style="font-family: 'Times New Roman'; background: #f5f5f5;">On the day of blood capture and during the previous 7 days, retrospectively recorded the geomagnetic Ap-index, using a publicly available information resource</span><span style="font-family: 'Times New Roman';"> </span><a href="http://wdc.kugi.kyoto-u.ac.jp/kp/index.html"><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #000000; mso-bidi-font-weight: bold; font-size: 10,0000pt;">http://wdc.kugi.kyoto-u.ac.jp/kp/index.html</span></a><span style="font-family: 'Times New Roman';">. </span><span class="15" style="font-family: 'Times New Roman'; background: #f5f5f5;">Results.</span><span style="font-family: 'Times New Roman'; background: #f5f5f5;"> </span><span class="15" style="font-family: 'Times New Roman'; background: #f5f5f5;">During the week, the average level of Ap-index ranged from 12÷20 nT.</span><span style="font-family: 'Times New Roman'; background: #f5f5f5;"> </span><span class="15" style="font-family: 'Times New Roman'; background: #f5f5f5;">The correlation coefficients between the Ap-index on the day of blood collection and 1, 3 and 7 days before it and the level of CD3</span>^{<span class="15" style="font-family: 'Times New Roman'; vertical-align: super; background: #f5f5f5;">+</span>}<span class="15" style="font-family: 'Times New Roman'; background: #f5f5f5;">CD4</span>^{<span class="15" style="font-family: 'Times New Roman'; vertical-align: super; background: #f5f5f5;">+</span>}<span class="15" style="font-family: 'Times New Roman'; background: #f5f5f5;"> lymphocytes were </span><span style="font-family: 'Times New Roman';">-0,57; -0,48; -0,55 і -0,52 </span><span style="font-family: 'Times New Roman'; background: #f5f5f5;">respectively, while on other days were in the range of</span><span style="font-family: 'Times New Roman';"> -0,35÷0,05. </span><span style="font-family: 'Times New Roman'; background: #f5f5f5;">In contrast, with the level of CD56</span>^{<span style="font-family: 'Times New Roman'; vertical-align: super; background: #f5f5f5;">+</span>}<span style="font-family: 'Times New Roman'; background: #f5f5f5;"> lymphocytes Ap-index correlates positively and almost mirror</span><span style="font-family: 'Times New Roman';"> (0,56; 0,43; 0,54 і 0,57 </span><span style="font-family: 'Times New Roman'; background: #f5f5f5;">respectively</span><span style="font-family: 'Times New Roman';"> and 0,34÷-0,08), </span><span style="font-family: 'Times New Roman'; background: #f5f5f5;">due to the reciprocity of their levels</span><span style="font-family: 'Times New Roman';"> (r=-0,80). </span><span style="font-family: 'Times New Roman';">Also positive, but much weaker, correlates the Ap-index with the level of</span><span style="font-family: 'Times New Roman';"> CD25</span>^{<span style="font-family: 'Times New Roman'; vertical-align: super;">+</span>}<span style="font-family: 'Times New Roman';"> </span><span class="15" style="font-family: 'Times New Roman'; background: #f5f5f5;">lymphocytes</span><span style="font-family: 'Times New Roman';"> (0,35; 0,25; 0,45 і 0,31 </span><span style="font-family: 'Times New Roman'; background: #f5f5f5;">respectively</span><span style="font-family: 'Times New Roman';"> and 0,22÷-0,14). </span><span style="font-family: 'Times New Roman'; background: #f5f5f5;">In contrast, with the level of IL-1β Ap-index correlates significantly only on the day of blood collection and 2 days before</span><span style="font-family: 'Times New Roman';"> (r=0,21 and 0,31 </span><span style="font-family: 'Times New Roman'; background: #f5f5f5;">respectively</span><span style="font-family: 'Times New Roman';">), </span><span class="15" style="font-family: 'Times New Roman'; background: #f5f5f5;">and with other registered parameters of immunity the correlation is insignificant.</span><span style="font-family: 'Times New Roman'; background: #f5f5f5;"> </span><span class="15" style="font-family: 'Times New Roman'; background: #f5f5f5;">The canonical correlation between Ap-indices for 7 days before and on the day of blood collection, on the one hand, and the levels of</span><span style="font-family: 'Times New Roman';"> CD4</span>^{<span style="font-family: 'Times New Roman'; vertical-align: super;">+</span>}<span style="font-family: 'Times New Roman';">, CD56</span>^{<span style="font-family: 'Times New Roman'; vertical-align: super;">+</span>}<span style="font-family: 'Times New Roman';">, CD25</span>^{<span style="font-family: 'Times New Roman'; vertical-align: super;">+</span>}<span style="font-family: 'Times New Roman';"> and CD8</span>^{<span style="font-family: 'Times New Roman'; vertical-align: super;">+</span>}<span class="15" style="font-family: 'Times New Roman'; background: #f5f5f5;"> lymphocytes and the concentration of IgM and IL-1β - on the other hand, was very strong</span><span style="font-family: 'Times New Roman';">: R=0,741; R</span>^{<span style="font-family: 'Times New Roman'; vertical-align: super;">2</span>}<span style="font-family: 'Times New Roman';">=0,549; χ</span>^{<span style="font-family: 'Times New Roman'; vertical-align: super;">2</span>}_{<span style="font-family: 'Times New Roman'; vertical-align: sub;">(42)</span>}<span style="font-family: 'Times New Roman';">=130; p<10</span>^{<span style="font-family: 'Times New Roman'; vertical-align: super;">-6</span>}<span style="font-family: 'Times New Roman';">.

</span><span class="15" style="font-family: 'Times New Roman'; background: #f5f5f5;">Conclusion.</span><span style="font-family: 'Times New Roman'; background: #f5f5f5;"> </span><span style="font-family: 'Times New Roman'; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">Disturbances</span><span class="15" style="font-family: 'Times New Roman'; background: #f5f5f5;"> of the geomagnetic field (Ap-index) has a significant immediate modulating effect on the level of immune parameters in the blood, mostly T-helpers (suppressor) and natural killers (enhancing).</span></p>