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Significant rise in SARS-CoV-2 reinfection rate in vaccinated Hospital workers during the omicron wave: A prospective cohort study

Background: Relatively low SARS-CoV-2 reinfection rates have been reported in vaccinated individuals, but updates considering the Omicron variant are lacking. Objective: The objective of the study was to provide a current estimate of the SARS-CoV-2 reinfection rate in a highly immunized population....

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Main Authors: Eric Ochoa-Hein (Author), Patricia E. Leal-Morán (Author), Karen A. Nava-Guzmán (Author), Abril T. Vargas-Fernández (Author), José F. Vargas-Fernández (Author), Fabricio Díaz-Rodríguez (Author), Joel Armando Rayas-Bernal (Author), Ricardo González-González (Author), Pavel Vázquez-González (Author), Martha A. Huertas-Jiménez (Author), Sandra Rajme-López (Author), Pilar Ramos-Cervantes (Author), Violeta Ibarra-González (Author), Luis A. García-Andrade (Author), Fernando Ledesma-Barrientos (Author), Alfredo Ponce- (Author), José Sifuentes-Osornio (Author), Arturo Galindo-Fraga (Author)
Format: Book
Published: Permanyer, 2022-10-01T00:00:00Z.
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Summary:Background: Relatively low SARS-CoV-2 reinfection rates have been reported in vaccinated individuals, but updates considering the Omicron variant are lacking. Objective: The objective of the study was to provide a current estimate of the SARS-CoV-2 reinfection rate in a highly immunized population. Methods: A prospective cohort of Mexican hospital workers was followed (March 2020-February 2022). Reinfection was defined as the occurrence of two or more episodes of COVID-19 separated by a period of ≥ 90 days without symptoms. The reinfection rate was calculated as the number of reinfection episodes per 100,000 persons per day. Results: A total of 3732 medical consultations were provided to 2700 workers, of whom 1388 (51.4%) were confirmed COVID-19 cases. A total of 73 reinfection cases were identified, of whom 71 (97.3%) had completed their primary vaccination series and 22 (30.1%) had had a booster dose before the second episode. The overall reinfection rate was 23.1 per 100,000 persons per day (as compared to a rate of 1.9 per 100,000 persons per day before the Omicron wave). Conclusions: The SARS-CoV-2 reinfection rate rose significantly during the Omicron wave despite a high primary vaccination coverage rate. Almost one-third of reinfected workers had a vaccine booster ≥ 14 days before the last COVID-19 episode.
Item Description:10.24875/RIC.22000159
0034-8376
2564-8896

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