Pregestational Diabetes and Congenital Heart Defects

Abstract Studies have consistently shown a significant increase in the risk of congenital heart defects in the offspring of diabetic mothers compared with those of nondiabetic pregnancies. Evidence points that all types of pregestational diabetes have the capacity of generating cardiac malformations...

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Bibliographic Details
Main Authors: Catarina Maduro (Author), Luís Ferreira de Castro (Author), Maria Lúcia Moleiro (Author), Luís Guedes-Martins (Author)
Format: Book
Published: Federação Brasileira das Sociedades de Ginecologia e Obstetrícia, 2023-01-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Catarina Maduro  |e author 
700 1 0 |a Luís Ferreira de Castro  |e author 
700 1 0 |a Maria Lúcia Moleiro  |e author 
700 1 0 |a Luís Guedes-Martins  |e author 
245 0 0 |a Pregestational Diabetes and Congenital Heart Defects 
260 |b Federação Brasileira das Sociedades de Ginecologia e Obstetrícia,   |c 2023-01-01T00:00:00Z. 
500 |a 0100-7203 
500 |a 10.1055/s-0042-1755458 
520 |a Abstract Studies have consistently shown a significant increase in the risk of congenital heart defects in the offspring of diabetic mothers compared with those of nondiabetic pregnancies. Evidence points that all types of pregestational diabetes have the capacity of generating cardiac malformations in a more accentuated manner than in gestational diabetes, and there seems to be an increased risk for all congenital heart defects phenotypes in the presence of maternal diabetes. Currently, the application of some therapies is under study in an attempt to reduce the risks inherent to diabetic pregnancies; however, it has not yet been possible to fully prove their effectiveness. The present review aims to better understand the mechanisms that govern the association between pregestational diabetes and congenital heart defects and how maternal diabetes interferes with fetal cardiac development, as there is still a long way to go in the investigation of this complex process. 
546 |a EN 
546 |a PT 
690 |a pregestational diabetes 
690 |a diabetes mellitus 
690 |a hyperglycemia 
690 |a congenital heart defects 
690 |a Gynecology and obstetrics 
690 |a RG1-991 
655 7 |a article  |2 local 
786 0 |n Revista Brasileira de Ginecologia e Obstetrícia, Vol 44, Iss 10, Pp 953-961 (2023) 
787 0 |n http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032022001000953&lng=en&tlng=en 
787 0 |n http://www.scielo.br/pdf/rbgo/v44n10/1806-9339-rbgo-44-10-0953.pdf 
787 0 |n https://doaj.org/toc/0100-7203 
856 4 1 |u https://doaj.org/article/efec84d235a341cea16f57f1aebac86c  |z Connect to this object online.