Amplifying the efficacy of ALA-based prodrugs for photodynamic therapy using nanotechnology

• Main Authors: Liang Lou (Author), Shizhe Zhou (Author), Sijia Tan (Author), Menghua Xiang (Author), Wei Wang (Author), Chuang Yuan (Author), Liqian Gao (Author), Qicai Xiao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

5-aminolevulinic acid (ALA) is a clinically approved prodrug involved in intracellular Heme biosynthesis to produce the natural photosensitizer (PS) Protoporphyrin IX (PpIX). ALA based photodynamic therapy (PDT) has been used to treat various malignant and non-malignant diseases. However, natural AL...